1550-1562
| George Seton | |
| B: | 1550 |
| East Lothian, Scotland | |
| D: | Mar 1562 |
| Scotland | |
1551-1572
| Grizel Semple | |
| B: | 1551 |
| Blair, Ayrshire, Scotland | |
| D: | 8 Feb 1572 |
1551-1616
| Margaret Hamilton | |
| B: | 1551 |
| D: | 10 Feb 1616 |
1553-1602
| Robert Seton Winton | |
| B: | 1553 |
| 1684806, East Lothian, Scotland | |
| D: | 22 Mar 1602 |
| 1684806, East Lothian, Scotland | |
| Alexander (1st Earl of Dunfermline) Seton | |
| B: | 1555 |
| Seton, East Lothian, Scotland | |
| D: | 16 Jun 1622 |
| Killed at the Battle of Pinkie, Edinburgh, Mid Lothian, Scotland | |
1580-1601
| Lilias Drummond | |
| B: | 1580 |
| Seton, East Lothian, Scotland | |
| M: | 30 Aug 1598 |
| Pitmeddan, Midlothia, Scotland | |
| D: | 8 May 1601 |
| Dalgety, Fife, Scotland | |
1556-1616
| Margaret Seton | |
| B: | 1556 |
| 1684806, East Lothian, Scotland | |
| D: | 10 Feb 1616 |
| Scotland | |
1560-
| James Seton | |
| B: | 1560 |
1562-1635
| William Seton | |
| B: | 1562 |
| Dunbar Castle, East Lothian, Scotland | |
| D: | Jul 1635 |
| Kyllismore, Scotland | |
1531-1586
| George (5th Lord Seton) Seton | |
| B: | 1531 |
| Tranent, East Lothian, Scotland | |
| D: | 8 Jan 1586 |
| Seton, East Lothian, Scotland | |
1534-1604
| Isabel Hamilton | |
| B: | c1534 |
| Sanquhar, Dumfries-shire, Scotland | |
| D: | 13 Nov 1604 |
| Renfrew, Renfrewshire, Scotland | |
1508-1549
| George (4Th Lord Seton) Seton | |
| B: | 1508 |
| Seton, East Lothian, Scotland | |
| D: | 17 Jul 1549 |
| Culrosse, Fife, Scotland | |
1510-1549
| Elizabeth Hay | |
| B: | 1510 |
| Culross, Perthshire, Scotland | |
| D: | 1549 |
| Culross, Fife, Scotland | |
1485-1558
| Janet Hepburn | |
| B: | 1485 |
| Bothwell, Lanarkshire, Scotland | |
| D: | 10 May 1558 |
| East Lothian, Scotland | |
1481-1513
| George (3rd Lord Seton) Seton | |
| B: | 1481 |
| Thirlstone, Berwichshire, Scotland | |
| D: | 9 Sep 1513 |
| killed at the Battle of Flodden, Northumberland, England | |