| # | Children | Name | Born | Died | Father | Mother |
|---|
| 1 | | | b. Abt 1660 | | Sir Thomas Wriothesley, (maid. name 4th Earl of Souithampton) | Frances Seymour |
| 2 | | | b. Abt 1661 | | Sir Thomas Wriothesley, (maid. name 4th Earl of Souithampton) | Frances Seymour |
| 3 | | | b. 6 Jun 1635 | d. 20 Nov 1635 | Sir Thomas Wriothesley, (maid. name 4th Earl of Souithampton) | Rachel DeMassue, Countess of Southampton |
| 4 | | | b. 1637 | d. 29 Sep 1723 | Sir Thomas Wriothesley, (maid. name 4th Earl of Souithampton) | Rachel DeMassue, Countess of Southampton |
| 5 | | | b. 31 Oct 1638 | d. 1643 | Sir Thomas Wriothesley, (maid. name 4th Earl of Souithampton) | Rachel DeMassue, Countess of Southampton |
| 6 | | | b. 1640 | d. 7 Dec 1643 | Sir Thomas Wriothesley, (maid. name 4th Earl of Souithampton) | Rachel DeMassue, Countess of Southampton |
| 7 | Yes | | b. 1635 | d. 19 Sep 1690 | Sir Thomas Wriothesley, (maid. name 4th Earl of Souithampton) | Elizabeth Leigh |
English
1608 - 1667 (59 years)