| # | Children | Name | Born | Died | Father | Mother |
|---|
| 1 | | | b. 19 Aug 1515 | d. 21 Sep 1517 | Francis I (King of France) de Valois | Claude, Duchess of Brittany, Queen consort of France |
| 2 | | | b. 19 Aug 1515 | d. 21 Sep 1517 | Francis I (King of France) de Valois | Claude, Duchess of Brittany, Queen consort of France |
| 3 | | | b. 23 October 1515 | d. 18 September 1524 | Francis I (King of France) de Valois | Claude, Duchess of Brittany, Queen consort of France |
| 4 | | | b. 28 Feb 1517 | d. 10 Aug 1536 | Francis I (King of France) de Valois | Claude, Duchess of Brittany, Queen consort of France |
| 5 | Yes | | b. 31 Mar 1519 | d. 10 Jul 1559 | Francis I (King of France) de Valois | Claude, Duchess of Brittany, Queen consort of France |
| 6 | | | b. 10 August 1520 | d. 7 July 1537 | Francis I (King of France) de Valois | Claude, Duchess of Brittany, Queen consort of France |
| 7 | | | b. 22 Jan 1522 | d. 9 Sep 1545 | Francis I (King of France) de Valois | Claude, Duchess of Brittany, Queen consort of France |
| 8 | | | b. 05 Jun 1523 | d. 15 Sep 1574 | Francis I (King of France) de Valois | Claude, Duchess of Brittany, Queen consort of France |
| 9 | | | b. 1524 | d. 1525 | Francis I (King of France) de Valois | Claude, Duchess of Brittany, Queen consort of France |
English
1499 - 1524 (24 years)