Friedrich married Alexandra, Princess of Hanover on 07 Jun 1904 in Gmunden, Austria. Alexandra, (daughter of Ernst August (Ernst August Wilhelm Adolf Georg Friedrich) Crown Prince of Hanover, 3rd Duke of Cumberland and Teviotdale and Princess Thyra Amelie Caroline Charlotte Anne Schleswig-Holstein-Sonderburg-Glücksburg) was born on 29 September 1882 in Schloss Ort, Gmunden, Upper Austria, Austria-Hungary Empire; died on 30 August 1963 in Glucksburg Castle, Glucksburg, Flensburg, Schleswig-Holstein, West Germany. [Group Sheet] [Family Chart]

1. Hereditary Grand Duke Friedrich Franz V of Mecklenburg-Schwerin was born on 22 Apr 1910 in Schwerin, Mecklenburg-Vorpommern, Grand Duchy of Mecklenburg-Schwerin; died on 31 Jul 2001 in Blankenese, Stadt Hamburg, Hamburg, Germany.
2. Christian Ludwig, Duke of Mecklenburg-Schwerin was born on 29 Sep 1912 in Ludwigslust, Mecklenburg-Vorpommern, Grand Duchy of Mecklenburg-Schwerin; died on 18 Jul 1996 in Eckernförde, Rendsburg-Eckernforde, Schleswig-Holstein, Germany.
3. Duchess Olga of Mecklenburg-Schwerin was born in 1916 in Ludwigslust, Mecklenburg-Vorpommern, Grand Duchy of Mecklenburg-Schwerin; died in 1917 in Ludwigslust, Mecklenburg-Vorpommern, Grand Duchy of Mecklenburg-Schwerin.
4. Duchess Thyra of Mecklenburg-Schwerin was born on 18 Jun 1919 in Sorgenfri Palace, Isle of Seeland, Kobenhavn, Denmark; died on 27 Sep 1981 in Glücksburg Castle, Glücksburg , Flensburg, Schleswig-Holstein, Germany.
5. Anastasia Alexandrine Cecile Marie Luise Wilhelmine Mecklenburg-Schwerin was born on 11 Nov 1923 in Mecklenburg, Germany; died on 25 Jan 1979 in Hamburg, Stadt Hamburg, Hamburg, West Germany.